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Scientific Publication

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Barrier dysfunction in the nasal allergy

Ayumi Fukuoka, Tomohiro Yoshimoto

In this review, the authors describe the importance of the epithelial barrier and the relationship between TJ disruption and allergic diseases. In addition, they discuss new findings regarding the association of TJ disruption and exacerbation of allergic rhinitis induced by diesel exhaust particles. As a main conclusion the authors highlight that the protection of the epithelial barrier function might prevent or inhibit the development or exacerbation of allergic rhinitis.

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Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview

Núria Piqué, María del Carmen Gómez-Guillén and María Pilar Montero

Disruption of the epithelial barrier function has been recently associated with a variety of diseases, mainly at intestinal level, but also affecting the respiratory epithelium and other mucosal barriers. Non-pharmacological approaches such as xyloglucan, with demonstrated protective barrier properties, are proposed as new alternatives for the management of a wide range of diseases, for which mucosal disruption and, particularly, tight junction alterations, is a common characteristic.

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New scientific publication on Mucoprotection and diarrheal processes.

Szajewska H, Kołodziej M, Łukasik J. Drug development and acute gastrointestinal infections. Expert Opin Investig Drugs. 2017 Dec 26:1-6

Clarifying the role of intestinal mucus in reducing inflammation and infection has led to the development of ‘mucosal protectors’. These agents form a bioprotective film in the gastrointestinal tract and potentially may prevent microorganisms from crossing the mucus barrier. To date, the most widely studied substances include xyloglucan (Xilaplus®) and gelatin tannate (Tasectan®, Gelenterum®). 2 new clinical studies are about to start to increase the body of evidence of those substances. Szajewska H, Kołodziej M, Łukasik J. Drug development and acute gastrointestinal infections. Expert Opin Investig Drugs. 2017 Dec 26:1-6

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Let's meet in..

2018, May 26

EAACI 2018

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2018, May 28

PharmaVenue May 2018

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2018, Jun 11

EuroPLX 67

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2018, Aug 29

FNM 2018

FNM-2018-Amsterdam
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2018, Oct 24

UEG Week 2018

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