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Barrier Technology

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New scientific evidence reinforces usefulness of the mucoprotective approach

M. Lanza1, I. Paterniti1, M. Campolo1 ,G. Casili1 , A. Filippone1,A. Peritore1, S. Cuzzocrea1,2 ,E. Esposito1 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina- Messina, Italy 2Department of Pharmacological and Physiological Science, Saint Louis University, South Grand Blvd St. Louis, Missouri, USA

A team of investigators led by Prof Cuzoccrea at the University of Messina has demonstrated in an in vivo study the beneficial effect on candida albicans infection of a medical device consisting of pea protein and grape seed extract due to their protective barrier properties. The results are new evidence of the muco-protective effects of some natural polymers against mucosa invasion by microorganisms.

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Antibiotic-Resistant Infection Treatment Costs Have Doubled Since 2002, Now Exceeding $2 Billion Annually.

Thorpe KE, Joski P, Johnston KJ.

Kenneth Thorpe, from Emery University in Atlanta, and his colleagues found in a study carried out in the USA, that while the overall number of bacterial infections remained relatively constant between 2002 and 2014, rising from 13.5 million to 14.3 million annually, the proportion that were antibiotic-resistant rose dramatically, from 5.2% to 11.0%. Patients with antibiotic-resistant infections had spending for bacterial infection that was 165 percent higher than spending by patients without such infections. Sixty-one percent of antibiotic-resistant infections were associated with urinary tract infections. Their conclusion is that the direct costs and the mortality and morbidity attributable to antibiotic-resistant infections make a compelling case for urgent action by national and international policy makers.

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Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview

Núria Piqué, María del Carmen Gómez-Guillén and María Pilar Montero

Disruption of the epithelial barrier function has been recently associated with a variety of diseases, mainly at intestinal level, but also affecting the respiratory epithelium and other mucosal barriers. Non-pharmacological approaches such as xyloglucan, with demonstrated protective barrier properties, are proposed as new alternatives for the management of a wide range of diseases, for which mucosal disruption and, particularly, tight junction alterations, is a common characteristic.

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