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Technological solution

The epithelium covers the entire surface of the body. It also covers cavities and tubes like the digestive tract, respiratory tract or vagina.

The mucin from the mucosal barrier acts mechanically by separating and taking away harmful external agents, such as bacteria or their toxins, viruses, parasites and various allergens, before they damage the epithelial cells.

If the mucosal barrier is damaged or defective, the harmful agents can stick to the epithelial cells and penetrate the organism.

This intrusion immediately triggers a defensive immune response which causes inflammation in the surrounding tissues. This first phase of inflammation causes another problem: the opening of the intercellular tight junctions which are the main barrier mechanism of the epithelium. The tight junctions hold the cells of the epithelium together acting as an impermeable barrier to stop the transfer of external agents into the organism.

When the tight junctions are disrupted by the effect of inflammation or external agents, the barrier fails and a massive invasion occurs which triggers a further immune response and so more inflammation. This inflammatory process produces symptoms such as swelling, redness, pain, extravasation and loss of function. This can result, for example, in abdominal pain and diarrhea in the intestine, vaginitis in the vagina and rhinitis in the upper respiratory system.

Mucoprotectors are polymers that act in the same way as the natural mucin of the mucosal barrier: they mechanically protect the epithelia wherever they are applied and prevent harmful agents from sticking to or penetrating the organism. The inflammatory reaction and subsequent opening of the tight junctions are prevented. This stops the vicious circle that leads to illness.

What’s more, the harmful agents that have already entered become isolated and, without further reinforcements, are neutralized by the patient's immune system.

Open tight junctions are mechanically protected, limiting the entry of harmful agents and restoring their barrier function. The body can then fight the illness in a natural way.

Mucoprotectors reproduce the mechanical action of the mucin when the mucosal barrier is damaged. They break the vicious circle that exacerbates the illness and allow the body to neutralize the aggression by itself.

Mucoprotectores are well tolerated, they are not absorbed, have no pharmacological effects and respect body functions. As such, they offer the patient an alternative solution.

References:
France M. and Turner J. The mucosal barrier at a glance. Journal of Cell Science 2017; 130: 307-314
Authimoolam S. and Dziubla T. Biopolymeric mucin and synthetic polymer analogs: their structure, function and role in biomedical applications. Polymers 2016: 8, 71
RibetD. and Cossart P.How bacterial pathogens colonize their hosts and invade deeper tissues. Microbes and Infection 2015; 17:173-183
Ulluwisheva D. et al. Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr 2011; 141: 769-776
Cozens D. and Read R. Antiadhesion methods as novel therapeutics for bacterial infections. Expert Rev Anti Infect Ther 2012; 10: 1457-1468
Sattin S. and Bernardi A. Glycoconjugates and glycomimetics as microbial anti-adhesives. Trends in Biotechnology 2016: 34: 483-495
Authimoolam S. and Dziubla T. Biopolymeric mucin and synthetic polymer analogs: their structure, function and role in biomedical applications. Polymers 2016: 8, 71

Last updated: 07/09/2017

Latest news about our technological solution

The epithelium is a barrier made up of epithelial cells, tight junctions and mucin, which create an impermeable barrier stopping the free flow of material from outside.
epithelium damaged
When the mucous membrane is damaged, the external harmful agents (bacteria, parasites, etc.) can come into contact with the epithelial cells.
pathogens antigens entering
One effect of the inflammation is the opening of tight junctions allowing more pathogens or antigens to enter. This can result, for example, in abdominal pain and diarrhoea, vaginitis and rhinitis.
Mucoprotector polymers
The application of a mucoprotector - polymers that act in the same way as the mucin - protects from pathogen or antigen penetration. Mucoprotectors are well tolerated, they are not absorbed, have no pharmacological effects and respect body functions.