Scientific Publication

3

AGA Abstracts Tu1254 - Protective Effect of Mucoprotectants and Prebiotic Combination on Gut Barrier Impairment and Visceral Hypersensitivity Induced by an Acute Stress in Rat

HeleneEutamene, FannyPlacide, ValerieTondereau, VassiliaTheodorou

BACKGROUND: Irritable Bowel Syndrome (IBS) is a common disorder characterized by visceral hypersensitivity and increased intestinal permeability. Stressful events can affect the onset and course of IBS. In rats, stress also induces visceral hypersensitivity and gut hyperpermeability. Mucoprotectant agents such as gelatin tannate and xyloglucan, have been shown to provide protection to the intestinal mucosa and to exert anti-diarrheal effects. On the other hand, prebiotics exert beneficial effect on the gut via a bifidogenic effect into the colon. Therefore, the aims of this study were to evaluate the effect of an acute vs a chronic treatment of a compound containing mucoprotectants (xyloglycan (XYL), pea proteins and tannins from grape (PPT) and a prebiotic (xylo-oligosaccharides (XOS) on visceral hypersensitivity and gut hyperpermeability induced by an acute stress in rat.

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New scientific evidence reinforces usefulness of the mucoprotective approach

M. Lanza1, I. Paterniti1, M. Campolo1 ,G. Casili1 , A. Filippone1,A. Peritore1, S. Cuzzocrea1,2 ,E. Esposito1 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina- Messina, Italy 2Department of Pharmacological and Physiological Science, Saint Louis University, South Grand Blvd St. Louis, Missouri, USA

A team of investigators led by Prof Cuzoccrea at the University of Messina has demonstrated in an in vivo study the beneficial effect on candida albicans infection of a medical device consisting of pea protein and grape seed extract due to their protective barrier properties. The results are new evidence of the muco-protective effects of some natural polymers against mucosa invasion by microorganisms.

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Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview

Núria Piqué, María del Carmen Gómez-Guillén and María Pilar Montero

Disruption of the epithelial barrier function has been recently associated with a variety of diseases, mainly at intestinal level, but also affecting the respiratory epithelium and other mucosal barriers. Non-pharmacological approaches such as xyloglucan, with demonstrated protective barrier properties, are proposed as new alternatives for the management of a wide range of diseases, for which mucosal disruption and, particularly, tight junction alterations, is a common characteristic.

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