Publication on the antioxidant and wound-healing properties of EHO-85

The excess of free radicals in the wound environment contributes to its stagnation during the inflammatory phase, favouring hard-to-heal wounds. Oxidative stress negatively affects cells and the extracellular matrix, hindering the healing process. In this study the investigators evaluated the antioxidant and wound-healing properties of a novel multifunctional amorphous hydrogel-containing Olea europaea leaf extract (OELE) in different experimental  models.  Oxidative stress induced in human dermal fibroblasts and keratinocytes was normalized, and their viability increased with OELE co-treatment, thus evidencing a protective role. In addition to that EHO-85 produced an early and sustained wound-healing stimulating effect superior to controls in diabetic mice. The authors concluded that this novel amorphous hydrogel presents an important ROS (reactive oxygen species) scavenger capacity due to the high phenolic content of OELE, which protects skin cells from oxidative stress and contributes to the physiological process of wound healing

Casado-Diaz A et al Evaluation of Antioxidant and Wound-Healing Properties of EHO-85, a Novel Multifunctional Amorphous Hydrogel Containing Olea europaea Leaf Extract. Pharmaceutics 2022, 14, 349. https://doi.org/10.3390/pharmaceutics14020349