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AGA Abstracts Tu1254 - Protective Effect of Mucoprotectants and Prebiotic Combination on Gut Barrier Impairment and Visceral Hypersensitivity Induced by an Acute Stress in Rat

HeleneEutamene, FannyPlacide, ValerieTondereau, VassiliaTheodorou

BACKGROUND: Irritable Bowel Syndrome (IBS) is a common disorder characterized by visceral hypersensitivity and increased intestinal permeability. Stressful events can affect the onset and course of IBS. In rats, stress also induces visceral hypersensitivity and gut hyperpermeability. Mucoprotectant agents such as gelatin tannate and xyloglucan, have been shown to provide protection to the intestinal mucosa and to exert anti-diarrheal effects. On the other hand, prebiotics exert beneficial effect on the gut via a bifidogenic effect into the colon. Therefore, the aims of this study were to evaluate the effect of an acute vs a chronic treatment of a compound containing mucoprotectants (xyloglycan (XYL), pea proteins and tannins from grape (PPT) and a prebiotic (xylo-oligosaccharides (XOS) on visceral hypersensitivity and gut hyperpermeability induced by an acute stress in rat.

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Congresses: Noventure participates at the second edition of IBS Days

Noventure, as part of its ongoing activities in support of the launch of Gelsectan®, participated with a stand at the IBS Days 2018 in Bologne, Italy, May 17 - 19, 2018.   This meeting is intended to provide current views and a look to the future on the rapidly advancing field of IBS. One of the lectures was devoted to mucosal barrier and permeability, which is a hot topic among gastroenterologists specialized in IBS management.  Gelsectan® contains mucoprotectors which improve the resistance of the mucosal barrier and help restore its normal function.  It is intended to relieve and prevent IBS symptoms such as chronic or relapsing diarrhoea, pain and bloating.

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Let's meet in..

2019, Jun 03

euroPLX 70 Berlin

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2019, Jun 05

ESPGHAN 52

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2019, Jun 13

Réunion annuelle du Groupe Français de Neuro-Gastroentérologie GFNG 2019

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2019, Jun 14

Gastro Update Europe 2019

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2019, Sep 05

NeuroGASTRO 2019

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2019, Oct 19

UEG Week 2019

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