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Barrier Technology

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AGA Abstracts Tu1254 - Protective Effect of Mucoprotectants and Prebiotic Combination on Gut Barrier Impairment and Visceral Hypersensitivity Induced by an Acute Stress in Rat

HeleneEutamene, FannyPlacide, ValerieTondereau, VassiliaTheodorou

BACKGROUND: Irritable Bowel Syndrome (IBS) is a common disorder characterized by visceral hypersensitivity and increased intestinal permeability. Stressful events can affect the onset and course of IBS. In rats, stress also induces visceral hypersensitivity and gut hyperpermeability. Mucoprotectant agents such as gelatin tannate and xyloglucan, have been shown to provide protection to the intestinal mucosa and to exert anti-diarrheal effects. On the other hand, prebiotics exert beneficial effect on the gut via a bifidogenic effect into the colon. Therefore, the aims of this study were to evaluate the effect of an acute vs a chronic treatment of a compound containing mucoprotectants (xyloglycan (XYL), pea proteins and tannins from grape (PPT) and a prebiotic (xylo-oligosaccharides (XOS) on visceral hypersensitivity and gut hyperpermeability induced by an acute stress in rat.

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New scientific evidence reinforces usefulness of the mucoprotective approach

M. Lanza1, I. Paterniti1, M. Campolo1 ,G. Casili1 , A. Filippone1,A. Peritore1, S. Cuzzocrea1,2 ,E. Esposito1 1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina- Messina, Italy 2Department of Pharmacological and Physiological Science, Saint Louis University, South Grand Blvd St. Louis, Missouri, USA

A team of investigators led by Prof Cuzoccrea at the University of Messina has demonstrated in an in vivo study the beneficial effect on candida albicans infection of a medical device consisting of pea protein and grape seed extract due to their protective barrier properties. The results are new evidence of the muco-protective effects of some natural polymers against mucosa invasion by microorganisms.

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Antibiotic-Resistant Infection Treatment Costs Have Doubled Since 2002, Now Exceeding $2 Billion Annually.

Thorpe KE, Joski P, Johnston KJ.

Kenneth Thorpe, from Emery University in Atlanta, and his colleagues found in a study carried out in the USA, that while the overall number of bacterial infections remained relatively constant between 2002 and 2014, rising from 13.5 million to 14.3 million annually, the proportion that were antibiotic-resistant rose dramatically, from 5.2% to 11.0%. Patients with antibiotic-resistant infections had spending for bacterial infection that was 165 percent higher than spending by patients without such infections. Sixty-one percent of antibiotic-resistant infections were associated with urinary tract infections. Their conclusion is that the direct costs and the mortality and morbidity attributable to antibiotic-resistant infections make a compelling case for urgent action by national and international policy makers.

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Let's meet in..

2018, Nov 26

EuroPLX 68

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2018, Nov 29

PharmaVenue November 2018

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2019, Feb 25

euroPLX 69 London

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2019, Mar 15

EAU 19

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