Pediatrics

Publication of a systematic review and meta-analysis on the efficacy of gelatin tannate in acute diarrhea in children. Aim: To investigate by meta-analysis the efficacy of gelatin tannate (GT), a mucosal barrier protector, in children with acute gastroenteritis. Conclusion: GT significantly (p < 0.01) reduced stool frequency at 12 h as well as the number of patients with diarrhea or liquid stools at 24 h (p < 0.01), compared with placebo. No adverse events were reported in any of the RCTs analyzed. The unique mechanism and lack of systemic absorption of GT make this device an interesting addition to the current armamentarium for treating acute gastroenteritis in children.