Barrier-enforcing measures as treatment principle in allergic rhinitis: a systematic review.

Andersson M, Greiff L, Ojeda P, Wollmer P. Curr Med Res Opin. 2014 Jun;30(6):1131-7. doi: 10.1185/03007995.2014.882299. Epub 2014 Jan 30.2:3. Background and objectives: Barrier-enforcing measures have been suggested as treatment options for allergic rhinitis. This review identifies and describes the literature on the subject. Methods: Relevant publications were searched for [...]

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The therapeutic management of gut barrier leaking: the emerging role for mucosal barrier protectors.

L.R. Lopetuso, F. Scaldaferri, G. Bruno, V. Petito, F. FranceschI, A. Gasbarrini. European Review for Medical and Pharmacological Sciences. 2015; 19: 1068-1076 Objective: Gut barrier is a functional unit organized as a multi-layer system and its multiple functions are crucial for maintaining gut homeostasis. Numerous scientific evidences showed a significant [...]

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Undissociated gelatine tannate and xyloglucan prevent gut leakiness and mucosal inflammation induced by LPS: insights in the mechanism of action.

H. Eutamene. P1449. UEG journal. October 2016. Vol 4. Suppl. 1 Pag A651 Introduction: Gelatine tannate (GT) and xylogucan (XG) are commercially available in several countries for the oral treatment of diarrhea in children and adults. However, the mechanism of action remains poorly understood. Aims & Methods: Therefore, we aimed to [...]

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A new approach to the treatment of uncomplicated cystitis: results of a randomized placebo-controlled clinical trial.

Salvatorelli  N et al. Urologia Internationalis. Published on line: April 8, 2016 Objective: To assess the efficacy and safety of a new medical device (MD; a capsule whose main component is a cross-linked protein) in the prevention of uncomplicated cystitis recurrences. Methods: Adult women with acute cystitis symptoms and a [...]

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Efficacy and safety of a medical device versus placebo in the early treatment of patients with symptoms of urinary tract infection: a randomized controlled trial.

García-Larrosa  A et al. Clinical Microbiology 2016, 5:1 Background:  The objective of the study was to analyze the efficacy and safety of a medical device containing reticulated gelatin with hibiscus and propolis (RGHP) in the early treatment of patients with symptoms of urinary tract infection (UTI). Methods:  A double-blind, placebo-controlled [...]

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Xyloglucan, hibiscus and propolis for the prevention of urinary tract infections: results of in vitro studies.

Fraile B et al. Future Microbiology. Published online: 27 March 2017 Aim: To assess the properties of a medical device containing xyloglucan, propolis and hibiscus to create a bioprotective barrier to avoid the contact of uropathogenic Escherichia coli strains on cell walls in models of intestinal (CacoGoblet) and uroepithelial (RWPE-1) [...]

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Gelatin tannate ameliorates acute colitis in mice by reinforcing mucus layer and modulating gut microbiota composition: Emerging role for ‘gut barrier protectors’ in IBD?

Franco Scaldaferri Loris Riccardo Lopetuso1, Valentina Petito, et al. United European Gastroenterology Journal 2014, Vol. 2(2) 113–122 Background: Gelatin tannate, a gelatin powder containing tannic acids, is commonly employed as an intestinal astringent. Neither information nor animal model exist to confirm its efficacy or unravel mechanisms of action. Objective: To [...]

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Xyloglucan for the treatment of acute diarrhea: results of a randomized, controlled, open-label, parallel group, multicentre, national clinical trial.

Lucio Gnessi, Vladimir Bacarea, Marius Marusteri and Núria Piqué. BMC Gastroenterology (2015) 15:153 Background: There is a strong rationale for the use of agents with film-forming protective properties, like xyloglucan, for the treatment of acute diarrhea. However, few data from clinical trials are available. Methods: A randomized, controlled, open-label, parallel [...]

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CPHI 2025

Frankfurt, Germany 20-30 October 2025 Noventure will attend the CPHI (Frankfurt, 28-30 October 2025)  Arrange a meeting with us to learn more about our products and license availability in the different countries. ¡Meet us at our Stand #4.1L30! Contact us: https://noventure.com/contact-us Event site [...]

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