A randomized controlled trial comparing a xyloglucan-based nasal spray with saline in adults with symptoms of rhinosinusitis.

Current Medical Research and Opinion 2017.  June 10: 1-17

Background:

This study assessed the efficacy, safety and tolerability of a xyloglucan-based nasal spray in the treatment of symptoms of rhinosinusitis.

Methodology:

In this randomized, double-blind study, 40 patients with itching, nasal congestion or continuous sneezing and a Total Nasal Symptom Score (TNSS) of ≥8 were randomized to 2 weeks' treatment with a xyloglucan-based nasal spray ('xyloglucan') or a physiological saline nasal spray ('saline'). Assessments included the TNSS, rhinosinusitis severity index, nocturnal awakenings, use of rescue medication, safety and tolerability.

Results:

Baseline symptom scores were similar between groups. At treatment end, improvements from baseline were observed in both groups for TNSS (xyloglucan 58%; saline 35%, both p < 0.05) and number of nocturnal awakenings (p < 0.05). A significant improvement in the rhinosinusitis severity index was observed only with xyloglucan (p < 0.05). At treatment end, mean [SD] scores were significantly lower in the xyloglucan group versus saline group for TNSS (3.60 [2.16] vs 5.40 [2.64], p < 0.05), rhinosinusitis severity index (7.55 [1.19] vs 6.45 [1.40], p < 0.05), and for rhinorrhoea and itching (both p < 0.05). No rescue medication was used. Both treatments were well tolerated.

Conclusions:

A xyloglucan-based nasal spray provided greater relief of rhinosinusitis symptoms than a physiological saline spray and was well tolerated.