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Magazine
Disruption of the epithelial barrier function has been recently associated with a variety of diseases, mainly at intestinal level, but also affecting the respiratory epithelium and other mucosal barriers. Non-pharmacological approaches such as xyloglucan, with demonstrated protective barrier properties, are proposed as new alternatives for the management of a wide range of diseases, for which mucosal disruption and, particularly, tight junction alterations, is a common characteristic.
Publication of a systematic review and meta-analysis on the efficacy of gelatin tannate in acute diarrhea in children.
Aim: To investigate by meta-analysis the efficacy of gelatin tannate (GT), a mucosal barrier protector, in children with acute gastroenteritis.
Conclusion: GT significantly (p < 0.01) reduced stool frequency at 12 h as well as the number of patients with diarrhea or liquid stools at 24 h (p < 0.01), compared with placebo.
No adverse events were reported in any of the RCTs analyzed. The unique mechanism and lack of systemic absorption of GT make this device an interesting addition to the current armamentarium for treating acute gastroenteritis in children.
The application of Rhinosectan® to nasal epithelial cells does not impair ciliary movement, enhances mucociliary clearance and facilitates phagocytosis while reducing mucin secretion, which are optimal properties for the management of rhinitis and associated conditions.