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Allergy as an epithelial barrier disease

Pirkko Mattila, Sakari Joenväärä, Jutta Renkonen, Sanna Toppila-Salmi and Risto Renkonen

Clinical and Translational Allergy20111:5 The objective of this review is to focus on putative modified epithelial functions related to allergy. The dysregulation of the epithelial barrier might result in the allergen uptake, which could be the primary defect in the pathogenesis of allergic...

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Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

Dulantha Ulluwishewa, Rachel C. Anderson, Warren C. McNabb, Paul J. Moughan, Jerry M. Wells, and Nicole C. Roy.

J. Nutr. May 1, 2011, vol. 141 no. 5 769-776 The human intestinal epithelium is formed by a single layer of epithelial cells that separates the intestinal lumen from the underlying lamina propria. The space between these cells is sealed by tight junctions (TJ), which regulate the permeability...

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